{"id":139761,"date":"2024-03-26T11:20:59","date_gmt":"2024-03-26T11:20:59","guid":{"rendered":"https:\/\/www.paluniv.edu.ps\/eng\/?p=139761"},"modified":"2024-03-26T11:21:20","modified_gmt":"2024-03-26T11:21:20","slug":"is-the-%ce%b23-adrenoceptor-a-valid-target-for-the-treatment-of-obesity-and-or-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/www.paluniv.edu.ps\/eng\/is-the-%ce%b23-adrenoceptor-a-valid-target-for-the-treatment-of-obesity-and-or-type-2-diabetes\/","title":{"rendered":"Is the \u03b23-Adrenoceptor a Valid Target for the Treatment of Obesity and\/or Type 2 Diabetes?"},"content":{"rendered":"<p><strong>Abstract<\/strong><\/p><p>\u03b2<sub>3<\/sub>-Adrenoceptors mediate several functions in rodents that could be beneficial for the treatment of obesity and type 2 diabetes. This includes promotion of insulin release from the pancreas, cellular glucose uptake, lipolysis, and thermogenesis in brown adipose tissue. In combination, they lead to a reduction of body weight in several rodent models including ob\/ob mice and Zucker diabetic fatty rats. These findings stimulated drug development programs in various pharmaceutical companies, and at least nine \u03b2<sub>3<\/sub>-adrenoceptor agonists have been tested in clinical trials. However, all of these projects were discontinued due to the lack of clinically relevant changes in body weight. Following a concise historical account of discoveries leading to such drug development programs we discuss species differences that explain why \u03b2<sub>3<\/sub>-adrenoceptors are not a meaningful drug target for the treatment of obesity and type 2 diabetes in humans.<\/p><p><strong>How to Cite<\/strong><\/p><p>Dwaib, H. S., &amp; Michel, M. C. (2023). Is the \u03b23-Adrenoceptor a Valid Target for the Treatment of Obesity and\/or Type 2 Diabetes?.&nbsp;<em>Biomolecules<\/em>,&nbsp;<em>13<\/em>(12), 1714.\u200f<strong><\/strong><\/p><p><strong>View at Publisher<\/strong><\/p><p><a href=\"https:\/\/www.mdpi.com\/2218-273X\/13\/12\/1714\">https:\/\/www.mdpi.com\/2218-273X\/13\/12\/1714<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Abstract \u03b23-Adrenoceptors mediate several functions in rodents that could be beneficial for the treatment of obesity and type 2 diabetes. This includes promotion of insulin release from the pancreas, cellular glucose uptake, lipolysis, and thermogenesis in brown adipose tissue. In combination, they lead to a reduction of body weight in several rodent models including ob\/ob [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":139762,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[540,529],"tags":[],"class_list":["post-139761","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-529"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/posts\/139761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/comments?post=139761"}],"version-history":[{"count":1,"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/posts\/139761\/revisions"}],"predecessor-version":[{"id":139763,"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/posts\/139761\/revisions\/139763"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/media\/139762"}],"wp:attachment":[{"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/media?parent=139761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/categories?post=139761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.paluniv.edu.ps\/eng\/wp-json\/wp\/v2\/tags?post=139761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}